Nrf2 for a key member of redox regulation: A novel insight against myocardial ischemia and reperfusion injuries - 11/11/23
, Caixia Guo a, ⁎ Abstract |
Nuclear factor erythroid-2 related factor 2 (Nrf2), a nuclear transcription factor, modulates genes responsible for antioxidant responses against toxic and oxidative stress to maintain redox homeostasis and participates in varieties of cellular processes such as metabolism and inflammation during myocardial ischemia and reperfusion injuries (MIRI). The accumulation of reactive oxygen species (ROS) from damaged mitochondria, xanthine oxidase, NADPH oxidases, and inflammation contributes to depraved myocardial ischemia and reperfusion injuries. Considering that Nrf2 played crucial roles in antagonizing oxidative stress, it is reasonable to delve into the up or down-regulated molecular mechanisms of Nrf2 in the progression of MIRI to provide the possibility of new therapeutic medicine targeting Nrf2 in cardiovascular diseases. This review systematically describes the generation of ROS, the regulatory metabolisms of Nrf2 as well as several natural or synthetic compounds activating Nrf2 during MIRI, which might provide novel insights for the anti-oxidative stress and original ideas targeting Nrf2 for the prevention and treatment in cardiovascular diseases.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | Oxidative stress contributes to the genesis and development of MIRI. |
• | A nuclear transcription factor Nrf2 affected the endogenous antioxidant genes and redox systems. |
• | The activation of Nrf2 alleviates oxidative stress to protect hearts from MIRI. |
• | Chemical compounds targeting Nrf2 might be a perspective view for the prevention and therapy of MIRI. |
Abbreviations : Nrf2, MIRI, ROS, SOD, HO-1, GPX, ARE, EpRE, XO, NOS, ATP, NOXs, O2−, OH−, H2O2, ETC, XOR, NO, Prxd, BZIP, Keap1, NTR, IVR, CTR, RAC3, β-TrCP, GSK3β, RXRα, PPARγ, RAR, ER, NQO1, NAC, 4-HNE, eNOS, Hsf1, NFIL3, MEF, NF-κB, Map3k6, EGF, VEGF, TGF, NResF1, OGD/R, CO, IPC, HUVECs, SFN, H2S, TFE, hCSCs, CoPP, MSC, FADs, DMF, MMF, MI, CABG, PCI
Keywords : Antioxidation, Lipid peroxidation, Myocardial ischemia and reperfusion injuries, Nrf2, ROS
Plan
Vol 168
Article 115855- décembre 2023 Retour au numéro
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