The role and mechanism of platelet-rich fibrin in alveolar bone regeneration - 11/11/23
Abstract |
Platelet-rich fibrin (PRF), as an autologous blood preparation, has been receiving increasing attention in recent years and has been successfully applied in various clinical treatments for alveolar bone regeneration in the oral field. This review focuses on analyzing and summarizing the role and mechanism of PRF in alveolar bone regeneration. We first provide a brief introduction to PRF, then summarize the mechanisms by which PRF promotes alveolar bone regeneration from three aspects: osteogenesis mechanism, bone induction mechanism, and bone conduction mechanism, involving multiple signaling pathways such as Smad, ERK1/2, PI3K/Akt, and Wnt/β-catenin. We also explore the various roles of PRF as a scaffold, filler, and in combination with bone graft materials, detailing how PRF promotes alveolar bone regeneration and provides a wealth of experimental evidence. Finally, we summarize the current applications of PRF in various oral fields. The role of PRF in alveolar bone regeneration is becoming increasingly important, and its role and mechanism are receiving more and more research and understanding. This article will provide a reference of significant value for research in related fields. The exploration of the role and mechanism of PRF in alveolar bone regeneration may lead to the discovery of new therapeutic targets and the development of more effective and efficient treatment strategies.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Multi-dimensionally explored PRF's mechanism of promoting bone regeneration. |
• | Thoroughly analyzed the role of PRF's three-dimensional fibrin scaffold structure. |
• | Summarized PRF's contribution to alveolar bone regeneration in-depth. |
• | Comprehensively provided a summary of the recent applications of PRF in the field of dentistry. |
Abbreviations : PRP, PRF, L-PRF, A-PRF, A-PRF+, I-PRF, T-PRF, PDGF, VEGF, TGF-β, IGF, EGF, HGF, BMP, qRT-PCR, BMSCs, TCP, RUNX2, OM, PDLSC, hBMSCs, OEC, pOB, OSX, OCN, ERK, MAPK, OPG, SMAD, ALP, ShcA, Grb2, Sos, Ras, Raf, MEK1/2, TAK1, TRAF6, MKK, JNK, p38MAPK, TF, FGF, Ang, PI3K, PDK1, AKT, TCF/LEF, Wnt, FZD, Dsh, GSK-3β, CBCT, PD, RAL, GML, DFDBA, CM, DBBM, ISQ, REC, NcHA, TCP, OFD, CAL, BS, MRONJ, MTA, BAF, OAC, VAS, ABSM, XBSM, SCAP, FDBA
Keywords : Platelet-rich fibrin, Alveolar bone regeneration, Osteogenesis, Signaling pathways, Scaffold
Plan
Vol 168
Article 115795- décembre 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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