The interplay between α-Synuclein and NLRP3 inflammasome in Parkinson's disease - 11/11/23
, Gang Hu a, b, ⁎ Abstract |
α-Synuclein is a member of a protein of synucleins, which is a presynaptic neuron protein. It is usually highly expressed in the brain and participates in the formation and transmission of nerve synapses. It has been reported that abnormal aggregation of α-Syn can induce the activation of NLRP3 inflammasome in microglia, increase the production of IL-1β, and aggravate neuroinflammation. Therefore, it is recognized as one of the important factors leading to neuroinflammation in Parkinson's disease. In this paper, we aimed to explore the influence of post-translational modification of α-Syn on its pathological aggregation and summarize various pathways that activate NLRP3 triggered by α-Syn and targeted therapeutic strategies, which provided new insights for further exploring the origin and targeted therapy of Parkinson's disease.
Le texte complet de cet article est disponible en PDF.Abbreviations : NLRP3, IL-1β, DA, Tyr, PP2A, Ser, O-GlcNAc, NOD, ASC, NF-κB, TLRs, TLR2, TLR4, THP1, TNF-α, mTOR, PL, p62/SQSTM1, AP-1, SVZ, miR-7, NADH-CoQ, NO, iNOS, ROS, TOM20, mtROS, DAMP, mtDNA, DAN, MPTP, MPP+, GABA, RhoA, NOX2, AMPK, AICAR, SIRT3, VDAC, MOMP, SMAC, DIABLO, IP3R, MyD88, TRIF, CMPK, dCTP, SN, MAPKs, CMA, LPS, MARCHF7/MARCH7, USP5, E3, ATP, UCH-LI, Ka, ATG5, GAG, wtTIDM, CA, JNK, CaMKK2, mTOR, BMDMs, HMDMs, PMCs, miR-30e, S1P, FTY720, GSK-3β
Keywords : Parkinson's disease, α-Synuclein, NLRP3, Pathophysiology, Neuroinflammation
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Vol 168
Article 115735- décembre 2023 Retour au numéro
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