Modulatory mechanisms of cannabinoids as a window of hope to patients with sleep-related cardiometabolic risk - 11/11/23
Doi : 10.1016/j.biopha.2023.115721
Miguel Meira e Cruz a, b, ⁎ 
a Sleep Unit, Centro Cardiovascular da Universidade de Lisboa, Lisbon School of Medicine, Lisbon, Portugal
b Centro Europeu do Sono, Lisbon, Portugal
⁎Corresponding author at: Sleep Unit, Centro Cardiovascular da Universidade de Lisboa, Lisbon School of Medicine, Lisbon, Portugal.Sleep Unit, Centro Cardiovascular da Universidade de Lisboa, Lisbon School of MedicineLisbonPortugal
Graphical Abstract |
:
Intersected pathways between circadian timing system (CTS), sleep regulatory centers (SLEEP=Backspace) and endocannabinoid system (CB) towards cardiometabolic dysfunctions and disorders (cardiometabolic risk). The stress role is affected, both by peripheral (oxidative signaling and proinflammatory activation) and central (autonomic reaction) factors that are eventually related with distinct mediators as cyclooxigenase, nitric oxide and orexin, between others.
Intersected pathways between circadian timing system (CTS), sleep regulatory centers (SLEEP=Backspace) and endocannabinoid system (CB) towards cardiometabolic dysfunctions and disorders (cardiometabolic risk). The stress role is affected, both by peripheral (oxidative signaling and proinflammatory activation) and central (autonomic reaction) factors that are eventually related with distinct mediators as cyclooxigenase, nitric oxide and orexin, between others.ga1Le texte complet de cet article est disponible en PDF.
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© 2023
The Authors. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 168
Article 115721- décembre 2023 Retour au numéro
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