Sialagogic Effects Through Olfactory Stimulation with Mastic Resin and α-pinene Volatiles in vivo - 11/11/23
, Kamran Nazmi a, Annina van Splunter a, Marja L. Laine b, Floris J. Bikker aAbstract |
Background |
Xerostomia, often associated with decreased saliva quality, poses challenges due to limited treatment efficacy. This study aimed to investigate alternative approaches to enhance saliva secretion through olfactory volatile stimulation with mastic resin and its main compound α-pinene, known for inhibiting acetylcholinesterase in vitro.
Methods |
The inhibitory effects of freshly prepared mastic resin extract oil and α-pinene oil on acetylcholinesterase (AChE) activity were measured in vitro. Eighty healthy participants were recruited and divided into two groups: exposed to mastic resin volatiles (n = 40) or α-pinene volatiles (n = 40). Saliva samples were collected pre, during and post exposure to analyze saliva flow rate, spinnbarkeit, ion composition and MUC5B levels.
Results |
Mastic resin extract oil and α-pinene oil inhibited AChE activity by 207 % and 22 %, respectively. Olfactory stimulation with these volatiles significantly increased saliva secretion rate without altering spinnbarkeit and ion composition. Salivary MUC5B concentration rose after exposure to mastic resin volatiles.
Conclusions |
Olfactory stimulation with mastic resin and α-pinene volatiles demonstrated a bona fide in vivo effect on saliva secretion, confirming their sialagogic capability, potentially as a result of local glandular AChE inhibition. These findings highlight the therapeutic potential of both volatile compounds in treating patients with xerostomia and hyposalivation through olfactory exposure.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Mastic resin extract oil and α-pinene oil inhibited acetylcholinesterase activity in vitro. |
• | Olfactory stimulation with mastic resin and α-pinene volatiles increased saliva secretion. |
• | Olfactory exposure to mastic resin and α-pinene volatiles did not alter the spinnbarkeit and ion composition of saliva. |
• | Salivary MUC5B concentration increased after mastic resin volatile stimulation. |
• | Olfactory exposure to mastic resin and α-pinene volatiles fosters potential treatment for xerostomia and hyposalivation. |
Keywords : Saliva, Xerostomia, Olfactory stimulation, Mastic resin volatiles, Acetylcholinesterase, α-pinene
Plan
Vol 168
Article 115699- décembre 2023 Retour au numéro
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