Dietary antioxidants and vascular calcification: From pharmacological mechanisms to challenges - 11/11/23
Abstract |
Vascular calcification (VC), an actively regulated process, has been recognized as an independent and strong predictor of cardiovascular disease (CVD) and mortality worldwide. Diet has been shown to have a major role in the progression of VC. Oxidative stress (OS), a common pro-calcification factor, is closely related to VC, and evidence strongly suggests that dietary antioxidants directly prevent VC. Herein, we provided an overview of OS and its key role in VC and underlined the mechanisms of harmful effects of OS on VC. Furthermore, we introduced dietary antioxidants, and discussed about surrounding the challenges of dietary antioxidants in VC management. This review will benefit future research about the effects of dietary antioxidants on cardiovascular health.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
The Figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.
The Figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.ga1Le texte complet de cet article est disponible en PDF.
Highlights |
• | Oxidative stress, an imbalance between reactive oxygen species and antioxidant defense, can induce vascular calcification. |
• | Various dietary antioxidants inhibit vascular calcification, including flavonoids, antioxidant vitamins and minerals, etc. |
• | The Mediterranean diet provides a good reference program in the management of vascular calcification. |
• | Dietary antioxidants provide promising apporoaches for the treatment or prevention of vascular calcification. |
Keywords : Dietary antioxidants, Vascular calcification, Oxidative stress, Cardiovascular disease
Plan
Vol 168
Article 115693- décembre 2023 Retour au numéro
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