Vanillic acid alleviates liver fibrosis through inhibiting autophagy in hepatic stellate cells via the MIF/CD74 signaling pathway - 11/11/23
Abstract |
MIF/CD74 signaling pathway and autophagy may be closely related to liver fibrosis. Vanillic acid (VA) is likely to have an anti-liver fibrosis effect, although related studies have not been reported. The aim of this study was to verify the role of hepatic stellate cells (HSCs) autophagy and the MIF/CD74 signaling pathway in the pathogenesis of liver fibrosis, and to investigate the effect of VA on liver fibrosis through in vivo and in vitro experiments. Our results showed that VA significantly attenuated CCl4-induced liver fibrosis. The alleviation of liver fibrosis with VA treatment was associated with a reduction of MIF, CD74, α-SMA, LC3B and Collagen 1. In addition, VA, MIF inhibitor (ISO-1) and autophagy inhibitor (3-MA) markedly inhibited the proliferation and migration of HSCs. This study indicates that VA could protect against HSCs activation, proliferation and migration by inhibiting the autophagy in HSCs via the MIF/CD74 signaling pathway so that alleviates liver fibrosis.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Vanillic acid may have significant anti-liver fibrosis effects. |
• | In liver fibrosis, autophagy of HSCs can be regulated by MIF/CD74 pathway. |
• | Activation, proliferation and migration of HSCs can be inhibited by autophagy. |
• | Vanillic acid alleviate liver fibrosis through MIF/CD74/autophagy pathway. |
Keywords : Vanillic acid, Liver fibrosis, Autophagy, Hepatic stellate cells, MIF/CD74
Plan
Vol 168
Article 115673- décembre 2023 Retour au numéro
Article précédent
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