Medication-related osteonecrosis of the jaw (MRONJ) is a most interesting, complex and “elusive” condition seen by the oral health care provider. It is plagued by controversy and although a wealth of research has created clinical treatment databases, there is no “gold standard” algorithm to be applied in a universal fashion. The purpose of this article is to explore several controversies associated with the etiology(s), staging, treatments, and long-term resolution of MRONJ in patients who are treated by the oral health care provider. Controversies for optimizing prevention, and disease control will also be discussed from an interdisciplinary perspective.