The aim of this investigation was to retrospectively evaluate the long-term implant loss rates and to identify associations between implant failure and patient-related factors in a sample of patients who had consecutively received implant therapy in ten dental universities in the United States using a large database.

Dental records of adult patients who had attended the dental clinics of the universities contributing data to the BigMouth network between 2011 and 2022 seeking dental therapy were evaluated. Information regarding patients’ characteristics including age, gender, ethnicity, race, tobacco use and systemic medical conditions were extracted from patients’ files.

A total of 20,842 patients who received 50,333 dental implants over a 12-year period (2011–2022) were included. The mean age of the cohort was 57.50±14.27 years which consisted of 51.8% females, 91.1% non-Hispanic, 66.3% white individuals and 8% tobacco users. In the univariate analysis, ethnicity, race and marijuana use were significantly associated with implant treatment outcome. Race and ethnicity were significantly associated with implant loss in the multivariate analysis. The implant failure rate was estimated to be 2.7% at the patient level and 1.4% at the implant level.

Within the limitations of this retrospective study that utilized records of 50,333 dental implants placed in ten institutions contributing data to the BigMouth network, the implant failure rate was estimated to be 2.7% at patient level and 1.4% at implant level. Ethnicity and race were significantly associated with implant failure, while none of the examined systemic conditions were associated with implant loss