Principles of transmucosal delivery of therapeutic agents - 19/05/08

Doi : 10.1016/j.biopha.2004.01.006

James Blanchette ^a, Nikhil Kavimandan ^b, Nicholas A. Peppas ^a,^b,⁎
^a Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
^b Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA

^*Corresponding author.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages	10
Iconographies	4
Vidéos	0
Autres	0

Abstract

Recent advances in medicine have led to new treatment options for patients and physicians as a more developed understanding of the molecular basis of disease states is translated into new therapeutic agents. Many of these new agents are compounds that are not able to reach the bloodstream when administered by the oral route preventing the ability to enjoy the benefits this delivery route provides such as lower cost and increased quality of life. Our laboratory has focused on the use of hydrogel carriers to increase the bioavailability of orally administered therapeutic agents ranging from proteins such as insulin to chemotherapeutics like bleomycin. The foundations of this research as well as recent advances are reviewed along with a discussion of the challenges of oral administration and other emerging strategies for oral administration.

Le texte complet de cet article est disponible en PDF.

Keywords : Oral administration, Hydrogels, Insulin, Chemotherapy, Transmucosal delivery, Protein delivery