Intermittent doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF) maintains a high level of viral suppression in virologically suppressed people living with HIV - 15/10/23
, Sanaa Saliba a, Stéphanie Landowski b, Basma Abdi c, Marc-Antoine Valantin a, Rezak Mahrez b, Christine Katlama a, Pierre de Truchis bHighlights |
• | ART given 5 or 4 days a week is now a suitable option for virally suppressed PLHIV. |
• | Prior to this study, intermittent DOR/3TC/TDF had never been investigated. |
• | In this retrospective analysis, we described 43 PLHIVs on intermittent DOR/3TC/TDF. |
• | Median duration of follow-up was 78 weeks. |
• | Only one virological failure occurred, with no emergence of resistance. |
Abstract |
Introduction |
We aimed to determine whether doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF) given 5 or 4 days a week was able to maintain viral suppression in people living with HIV (PLHIV).
Methods |
In this observational, retrospective study, we included all PLHIVs who had received intermittent DOR/3TC/TDF between 10/01/2019 and 01/31/2021, in two French hospitals.
Results |
Forty-three PLHIVs were included, median (IQR) age: 52 years (48–58), ART duration: 15 years (8–23), duration of virological suppression: 6 years (2–10). Median follow-up was 78 weeks (IQR 62–97). One virological failure (VF) occurred at W38 (HIV-RNA = 61 and 76 copies/mL), in a patient with no viral resistance at baseline or at time of VF, and during the study period five individuals discontinued DOR/3TC/TDF due to adverse events. There were no significant changes during follow-up in the CD4 count, CD4/CD8 ratio, body weight or residual viremia rate.
Conclusion |
These findings suggest the potential for intermittent DOR/3TC/TDF to maintain virological control.
Le texte complet de cet article est disponible en PDF.Keywords : Antiretroviral therapy, Intermittent, Doravirine, HIV, Short-cycle therapy
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Vol 53 - N° 7
Article 104736- octobre 2023 Retour au numéro
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