SARS-CoV-2–specific antibody and T-cell immunity in convalescents after infection wave in Beijing in late 2022 - 13/10/23
, Quanyi Wang a, c, ⁎
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s u m m a r y |
Objectives |
To evaluate SARS-CoV-2–specific antibody and T-cell responses in convalescents 5 months after infection wave in Beijing from December 2022 to January 2023 to prevent reinfection and severe disease.
Methods |
Convalescents and uninfected individuals vaccinated with different doses were enrolled to assess the IFNγ T-cell responses against SARS-CoV-2 prototype strain, BF.7, BQ.1, and XBB. Neutralizing antibodies against prototype strain, BF.7, BA.5, and XBB and immunoglobulin G antibody were further analyzed.
Results |
In convalescents, the IFNγ T-cell response was significantly higher than that of uninfected individuals (all P < 0.001), and the T-cell response against XBB had no significant difference from that of SARS-CoV-2 prototype strain and BF.7 and BQ.1 (all P > 0.05). The seropositive rates of IgG antibodies were 100% (303/303) with a median concentration of 90.52 (95% CI, 82.52–99.37). The neutralizing antibodies titers of convalescents against BF.7 and BA.5 were higher than that against the prototype strain (both P < 0.001), while XBB.1.5 was lower (P < 0.001). T-cell response, IgG and neutralizing antibodies had no significant difference in convalescents vaccinated with different doses (all P > 0.05).
Conclusions |
The immunities may have some protective effect against possible future outbreaks and severe diseases of COVID-19.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2, T-cell immunity, SARS-CoV-2–specific antibody, COVID-19
Plan
Vol 87 - N° 5
P. 413-419 - novembre 2023 Retour au numéro
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