Gender--once an afterthought despite its significant yet unspoken role in the average American’s daily life (public restrooms, clothes shopping, grooming, sports teams)--has become a fraught sociopolitical issue. The concept of gender as a construct, once relegated to the realm of Women’s and Gender Studies courses, went mainstream while concurrently, gender reveal parties have experienced a surge in popularity. Meanwhile, youth (and adults) have become increasingly comfortable exploring their gender identities and expression, which has led to an increase in inquiries regarding gender-affirming care--along with an accompanying backlash resulting in an increasing number of states attempting to enact restrictions and bans, effectively turning healthcare for transgender youth into the latest political battlefield. This section will define and provide an overview of common gender- and sexual orientation-related terminology and basic topics in order to establish an understanding for the remainder of the articles in this edition.