This case series describes the soft tissue changes following extraction treatment in two patients with diverse lip thickness, but with similar baseline parameters including: labial competence, soft tissue profile, patient's age, extraction protocol, methods of anchorage, malocclusion, crowding, treatment appliance and mechanics. The same treatment plan involved upper first premolar extractions and lingual appliance combined with skeletal anchorage. The lip thickness played a crucial role in these cases, since a similar change of the incisor position leads to a different profile variation. This difference could be explained by the differing initial lip thicknesses as the patient with thin lips showed a more pronounced profilometric change. The choice of the ideal treatment plan must be tailored to the individual patient, taking into account not only initial skeletal and dental factors but also soft tissue factors, as well as the treatment goals.