In vivo evaluation of Adipose-Derived Stem Cells (ADSCs) using Nanofat technique and chitosan conduit for peripheral nerve defect repair - 15/09/23
, Charline Gengler b, Tuan Le Van c, Benoit Daubail d, Pietro di Summa e, Narcisse Zwetyenga b, David Guillier fAbstract |
Introduction |
Nerve autograft is the gold standard for reconstruction of peripheral nerve loss. The alternative is the interposition of a synthetic regeneration conduit. The purpose of the study was to evaluate the in vivo feasibility and interest of Adipose-Derived Stem Cells (ADSCs) using the Nanofat technique and chitosan conduit for peripheral nerve defect repair.
Material and methods |
In vivo, after the creation of a 10 mm defect of the sciatic nerve, 2 groups were defined according to the nerve repair in rats: “chitosan” group (n = 10) and “chitosan and ADSCs” group (n = 10) with a clinical and paraclinical evaluation at 7 weeks.
Results |
The in vivo results seem to show that the adjunction of ADSCs was favorable clinically, histologically and functionally compare to a chitosan reconstruction alone.
Discussion |
Peripheral nerve repair with defect using a chitosan conduit associated with ADSCs would constitute a surgical alternative in a single surgical step.
Le texte complet de cet article est disponible en PDF.Keywords : Adipose-derived stem cells, Peripheral nerve reconstruction, Nanofat
Abbreviations : ADSCs, CMAP, MSCs
Plan
Vol 124 - N° 5
Article 101491- octobre 2023 Retour au numéro
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