Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms - 13/09/23

Doi : 10.1016/j.biopha.2023.115340

Yang-Yang Zhang ^a,^b,^{^{1
These authors contributed equally to this work.}}, Mao-Zhi Li ^a,^b,^{^{1
These authors contributed equally to this work.}}, Hui-Hui Shen ^a, Ayitila Abudukeyoumu ^c, Feng Xie ^d, Jiang-Feng Ye ^e, Feng-Yuan Xu ^f, Jian-Song Sun ^g, Ming-Qing Li ^a,^h,^⁎
^a Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People’s Republic of China
^b Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China
^c Department of Gynecology, Shanghai Jiading Maternal Child Health Hospital, Shanghai 201800, People’s Republic of China
^d Medical Center of Diagnosis and Treatment for Cervical and Intrauterine Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People’s Republic of China
^e Institute for Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138632, Singapore
^f Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
^g School of Life Science and Health Engineering, Jiangnan University, Wuxi 214122, People’s Republic of China
^h Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People’s Republic of China

^⁎Corresponding author at: Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People’s Republic of China.Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan UniversityShanghai200080People’s Republic of China

Abstract

Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides.

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Keywords : Ginsenosides, Autophagy, Apoptosis, EMT, Endometrium

Plan

Introduction

Classification, chemical structure, and pharmacokinetics of ginsenosides

Main molecular mechanisms of ginsenosides against endometrial cancer

Inducing apoptosis of endometrial cancer cells

Promotion of autophagy in endometrial cancer cells

Regulation of EMT in endometrial cancer

Ginsenosides and endometriosis

20(S)-PPD inhibits the development of endometriosis by promoting autophagy in endometrial stromal cells

20(S)-PPD enhances NK cell cytotoxicity and promotes endometrial stromal cell apoptosis

Ginsenoside Rg3 inhibits endometriosis through mTOR-related signaling pathways

Main molecular mechanisms of ginsenosides against endometritis

Conclusion

Ethics approval and consent to participate

Funding

CRediT authorship contribution statement

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Vol 166

Article 115340- octobre 2023 Retour au numéro

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Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms - 13/09/23

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