Investigation of escape mechanisms of SARS-CoV-2 Omicron sub-lineages and exploration of potential antibodies for XBB.1 - 06/09/23
Doi : 10.1016/j.jinf.2023.07.014
Feng Gao a, b, c, ⁎, 1 
a Department of Physics, School of Science, Tianjin University, Tianjin 300072, China
b Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China
c SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China
∗Correspondence to: Department of Physics, School of Science, Tianjin University, Tianjin, China.Department of Physics, School of Science, Tianjin UniversityTianjinChina
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Highlights |
• | Compared to the WT strain, the RBDs of BA.2, BQ.1.1, and XBB.1 bound S2K146 and BD-604 with higher binding free energy. |
• | Compared to BD-604, the RBDs of BA.2, BQ.1.1, and XBB.1 bound S2K146 with greater conformational stability. |
• | The diffAb-optimized antibody showed excellent binding to XBB.1 RBD, offering a new approach for COVID-19 treatment. |
© 2023
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 87 - N° 4
P. 354-357 - octobre 2023 Retour au numéro
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