Early switching from intravenous to oral antibiotic therapy in bone and joint infections associated with methicillin-susceptible Staphylococcus aureus bacteremia - 01/09/23
Highlights |
• | We evaluate early oral antibiotics switch in bone/joint infection (BJI) with S. aureus bacteremia. |
• | Failure to control BJI treated with an early oral (<14 days) switch vs later was similar. |
• | An early switch to oral antibiotics seems to be a safe therapeutic option in BJI with SA bacteremia. |
Abstract |
Objectives |
We aimed to evaluate the clinical outcomes of patients with bone and joint infection (BJI) associated with methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB) treated with early oral switch to oral antibiotics (before day 14) versus later or no switch.
Patients and methods |
We included all cases reported between January 2016 and December 2021 in the University Hospital of Reims.
Results |
Among 79 patients with BJI associated with MSSAB, 50.6% had an early switch to oral antibiotics, with median duration of intravenous antibiotics of 9 (IQR 6–11) days. The overall cure rate was 81% with follow-up of 6 months, and was 85.7% after excluding the 9 patients whose death was not related to BJI infection. Failure to control BJI did not differ between the two groups.
Conclusion |
An early (before day 14) switch to oral antibiotics may be a safe therapeutic option in BJI associated with MSSAB.
Le texte complet de cet article est disponible en PDF.Keywords : Bone and joint infections, Staphylococcus aureus bacteremia, Oral antibiotics
Plan
Vol 53 - N° 6
Article 104739- septembre 2023 Retour au numéro
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