Twelve-month follow-up after hospitalization for SARS-COV-2: Physiology improves, symptoms remain - 01/09/23
, Steffen Leth b, c, d, Andreas Fløe a, Charlotte Hyldgaard e, Tina Gissel f, Ayfer Topcu g, Lars Kristensen c, Lene Sønderskov Dahl h, Johannes Martin Schmid a, b, Søren Jensen-Fangel b, d, Elisabeth Bendstrup a, b
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Highlights |
• | Reduced diffusion capacity affects 39% of patients 12 months after hospitalization with COVID-19. |
• | Reduced diffusion capacity mainly affects patients hospitalized with severe COVID-19. |
• | Dyspnea, reported as an mMRC score ≥ 2, affects 20% of patients 12 months after hospitalization. |
• | Mild-to-moderate or severe fatigue was reported by 62% of patients at 12-month follow-up. |
Abstract |
Objectives |
Persistent symptoms on short-term follow-up after infection with COVID-19 are common, but long-term consequences have been insufficiently studied. The aim of this study was to characterize pulmonary function and ongoing symptoms 12 months after hospitalization with COVID-19.
Methods |
This prospective multicenter study included 222 patients hospitalized with PCR-confirmed COVID-19 in the Central Denmark Region. Disease severity was stratified using WHO Clinical Progression Scale. Clinical characteristics, pulmonary function test (PFT), 6-minute walk test (6MWT), and patient-reported outcome measures were collected at follow-up 3 and 12 months after discharge. Outcome measures from follow-up 3 months after discharge have previously been published.
Results |
A total of 179 (81%) patients completed the 12-month follow-up. Median age was 60 years (IQR 51, 69) and 58% were male patients. At 12-month follow-up 49.7% had a normal diffusion capacity for carbon monoxide (DLCO), while 39.4% had DLCO < 80%. The 6MWT distance increased significantly (29 m 95% CI 19, 40; p < 0.01). An mMRC score of 0 was reported by 51% and an mMRC ≥ 2 by 20%. The frequency and severity of fatigue, depression, and anxiety did not improve over time.
Conclusions |
The study found that impaired DLCO percentage is common 12 months after hospitalization with SARS-CoV-2 and reduction in DLCO percentage is associated to dyspnea.
Le texte complet de cet article est disponible en PDF.Keywords : Post-acute COVID-19 syndrome, long COVID, SARS-CoV-2, COVID-19, Respiratory function test
Abbreviations : 6MWD, 6MWDp, 6MWT, BMI, DLCO, FAS, FEV1, FVC, HADS, HADS-A, HADS-D, HFO, ICU, LFO, mMRC, NOT, PFT, PROMs, RD, WCP
Plan
Vol 53 - N° 6
Article 104686- septembre 2023 Retour au numéro
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