The Potential Impact of Preemptive Pharmacogenetic Genotyping in the Neonatal Intensive Care Unit - 22/08/23
Abstract |
Objective |
To evaluate the use of drugs with pharmacogenomic (PGx) guidelines from the Clinical Pharmacogenetics Implementation Consortium in early childhood.
Study design |
A retrospective observational study of patients admitted to the neonatal intensive care (NICU) between 2005 and 2018 with at least 1 subsequent hospitalization at or after 5 years of age was performed to determine PGx drug exposure. Data regarding hospitalizations, drug exposures, gestational age, birth weight, and congenital anomalies and/or a primary genetic diagnosis were collected. Incidence of PGx drug and drug class exposures was determined and patient specific factors predictive of exposure were investigated.
Results |
During the study, 19 195 patients received NICU care and 4196 (22%) met study inclusion; 67% received 1-2, 28% 3-4, and 5% 5 or more PGx-drugs in early childhood. Preterm gestation, low birth weight (<2500 g), and the presence of any congenital anomalies and/or a primary genetic diagnosis were statistically significant predictors of Clinical Pharmacogenetics Implementation Consortium drug exposures (P < .01, P < .01, P < .01, respectively).
Conclusions |
Preemptive PGx testing in patients in the NICU could have a significant impact on medical management during the NICU stay and throughout early childhood.
Le texte complet de cet article est disponible en PDF.Keywords : NICU, genomics, pharmacogenetic, precision medicine
Abbreviations : ADR, CHD, CPIC, ELBW, EMR, LBW, NBW, NICU, NSAID, PGx, VLBW, WES/WGS
Plan
Vol 259
Article 113489- août 2023 Retour au numéro
Article précédent
- How Race, Ethnicity, and Social Determinants of Health Are Reported in Three European Pediatric Journals
- Ayush D. Shah, Wadsworth A. Williams, Lainie Friedman Ross
- Hyperbilirubinemia Among Infants Born Preterm: Peak Levels and Association with Neurodevelopmental Outcomes
- Gonzalo Solis-Garcia, Kamini Raghuram, Sajit Augustine, M. Florencia Ricci, Marie St-Hilaire, Deepak Louis, Hala Makary, Junmin Yang, Prakesh S. Shah
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?