Long COVID in Children and Young after Infection or Reinfection with the Omicron Variant: A Prospective Observational Study - 22/08/23

Doi : 10.1016/j.jpeds.2023.113463

Snehal M. Pinto Pereira, PhD ^1,^⁎ , Anna Mensah, PhD ², Manjula D. Nugawela, PhD ³, Terence Stephenson, DM ³, Shamez N. Ladhani, PhD ^2,⁴, Emma Dalrymple, MSc ³, Jake Dudley ³, Kelsey McOwat, MSc ², Ruth Simmons, PhD ², Isobel Heyman, PhD ³, Terry Segal, MBChB ⁵, Malcolm G. Semple, PhD ^6,⁷, Laila Xu, BSc ³,
CLoCk Consortium^{^∗}
Study Group team members are listed in the Appendix.
Marta Buszewicz, Trudie Chalder, Esther Crawley, Bianca De Stavola, Tamsin Ford, Shruti Garg, Anthony Harnden, Dougal Hargreaves, Michael Levin, Vanessa Poustie, Calum Semple, Kishan Sharma, Olivia Swann, Elizabeth Whittaker

Roz Shafran, PhD ³
¹ Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, UK
² Immunisations and Vaccine Preventable Diseases, UK Health Security Agency, London, UK
³ UCL Great Ormond Street Institute of Child Health, London, UK
⁴ Paediatric Infectious Diseases Research Group, St. George's University of London, London, UK
⁵ University College London Hospitals NHS Foundation Trust, London, UK
⁶ NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
⁷ Respiratory Medicine, Alder Hey Children's Hospital, Liverpool, UK

^∗Reprint requests: Snehal M. Pinto Pereira, PhD, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, Gower St, London, WC1E 6BT.Division of Surgery & Interventional ScienceFaculty of Medical SciencesUniversity College LondonGower StLondonWC1E 6BT

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Abstract

To describe the prevalence of long COVID in children infected for the first time (n = 332) or reinfected (n = 243) with Omicron compared with test-negative children (n = 311). Overall, 12%-16% of those infected with Omicron met the research definition of long COVID at 3 and 6 months after infection, with no evidence of difference between cases of first positive and reinfected (P_χ2 = 0.17).

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Keywords : post COVID-19 condition, omicron, long COVID, young people, prospective

Abbreviations : COVID, CLoCk, SARS-CoV-2

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Article 113463- août 2023 Retour au numéro

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Long COVID in Children and Young after Infection or Reinfection with the Omicron Variant: A Prospective Observational Study - 22/08/23

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