Differential impacts between fat mass index and fat-free mass index on patients with COPD - 12/08/23
, Shiro Otake a, Kaori Sakurai a, Mamoru Sasaki b, Hiroaki Iijima c, Naoya Tanabe d, Kazuya Tanimura e, Kaoruko Shimizu f, Toru Shirahata g, Masaru Suzuki f, Susumu Sato d, h, Hidetoshi Nakamura g, Koichiro Asano i, Koichi Fukunaga aAbstract |
Background |
Differences in the clinical impacts of fat mass index (FMI) and fat-free mass index (FFMI) remain unclear in patients with chronic obstructive pulmonary disease (COPD). We hypothesized that FMI and FFMI have different impacts on 1) emphysema and 2) pulmonary function and health-related quality of life of COPD patients.
Methods |
Patients with COPD (n = 228), enrolled in a multicenter prospective 3-year cohort were classified into four groups based on baseline median FMI and FFMI values. Emphysema assessed as the ratio of low attenuation area to total lung volume (LAA%) on computed tomography, pulmonary function, and health-related quality of life assessed using the St. George's Respiratory Questionnaire (SGRQ) were compared.
Results |
The four groups had statistically significant differences in LAA%, pulmonary function, and SGRQ scores. The Low FMI Low FFMI group exhibited the highest LAA%, lowest pulmonary function, and worst SGRQ scores among the four groups. In addition, these differences were consistent over 3 years. Multivariate analysis showed that low FMI was associated with high LAA%, low inspiratory capacity/total lung capacity (IC/TLC), and carbon monoxide transfer coefficient (KCO). In contrast, low FFMI was associated with these factors as well as worse SGRQ scores.
Conclusion |
FMI and FFMI have different effects on the clinical manifestations of COPD. Both low fat and muscle mass contributed to severe emphysema, whereas only low muscle mass contributed to worse health-related quality of life in patients with COPD.
Le texte complet de cet article est disponible en PDF.Highlights |
• | FMI and FFMI have different effects on the clinical manifestations of COPD. |
• | Low FMI and FFMI values were independently associated with severe emphysema. |
• | Patients with decreased FMI and FFMI exhibited severe emphysema. |
• | Such patients also exhibited lung function abnormalities and poor HQOL scores. |
Keywords : COPD, Fat-free mass index, Fat mass index, Body composition
Plan
Vol 217
Article 107346- octobre 2023 Retour au numéro
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