Asymptomatic Plasmodium falciparum infection evades triggering a host transcriptomic response - 05/08/23
Doi : 10.1016/j.jinf.2023.06.013
Diana Ahu Prah 1
West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana
Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana
Department of Infection Biology, Faculty of Infectious and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, United Kingdom
Claire Dunican 2
Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, United Kingdom
Linda Eva Amoah
West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana
Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Mahdi Moradi Marjaneh
Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, United Kingdom
Myrsini Kaforou
Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, United Kingdom
Centre for Paediatrics and Child Health, Imperial College London, United Kingdom
Asa Nordgren
Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, United Kingdom
William Jones-Warner
Department of Infection Biology, Faculty of Infectious and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, United Kingdom
Yaw Aniweh
West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana
Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana
Gordon A. Awandare
West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana
Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana
Aubrey J. Cunnington ⁎, 3 
Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, United Kingdom
Centre for Paediatrics and Child Health, Imperial College London, United Kingdom
∗Correspondence to: Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, 24 Norfolk Place, St Mary’s Campus, London W2 1PG, United Kingdom.Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London24 Norfolk Place, St Mary’s CampusLondonW2 1PGUnited Kingdom
Julius Clemence Hafalla ⁎, 4
Department of Infection Biology, Faculty of Infectious and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, United Kingdom
∗Correspondence to: Department of Infection Biology, Faculty of Infectious and Tropical Medicine, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.Department of Infection Biology, Faculty of Infectious and Tropical Medicine, London School of Hygiene and Tropical MedicineKeppel StreetLondonWC1E 7HTUnited Kingdom
Graphical Abstract |
Highlights |
• | Blood transcriptome analysis of uninfected, asymptomatic, and symptomatic malaria. |
• | Strong transcriptional response to symptomatic P. falciparum infection. |
• | No detectable host transcriptional response to asymptomatic infection. |
• | Asymptomatic P. falciparum infection evades triggering a detectable host transcriptomic response. |
Plan
© 2023
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 87 - N° 3
P. 259-262 - septembre 2023 Retour au numéro
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