Could chronic HBV infection explain Beethoven's hearing loss? Implications for patients currently living with hepatitis B - 05/08/23
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Summary |
The cause of Ludwig van Beethoven's health deterioration, i.e., hearing loss and cirrhosis, have been subject to various studies. The genomic analysis of his hair indicates infection with the hepatitis B virus (HBV) at least 6 months prior to death. However, considering his first documented case of jaundice in the summer of 1821, second jaundice months prior to his death, and increased risk of hearing loss in HBV-infected patients, we offer an alternative hypothesis of chronic HBV infection as a cause of deafness and cirrhosis. According to it, HBV was acquired early, progressed from immune-tolerant to an immune-reactive phase, and triggered Beethoven's hearing issues when aged 28. Later, HBV infection entered the non-replication phase with at least two episodes of reactivation in the fifth decade of life accompanied by jaundice. More studies examining hearing loss in patients with chronic HBV infection are encouraged to better understand their potential otologic needs.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | We hypothesize that Beethoven’s hearing loss was due to a chronic HBV infection. |
• | Hearing loss is not classically attributed to hepatitis B. |
• | HBV infection increases the odds of sudden sensorineural hearing loss. |
• | Hearing loss in HBV patients should be communicated to hepatologists. |
• | More studies addressing otologic issues in hepatitis B are needed. |
Keywords : Ludwig van Beethoven, Hepatitis B virus, Cirrhosis, Hearing loss, Hepatology
Plan
Vol 87 - N° 3
P. 171-176 - septembre 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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