Humans have always referred to religion in History to make sense of disasters and epidemics, especially when science could not explain them. Religion has often been invoked as a mean of protection. The Covid outbreak in 2020 and the initial medical impotence brought up old fears, reminiscent of the plague for some people. Unable to rely on science only, some turned back to religion.

A narrative review was conducted to compare the role of religion during the Great Plague of Marseille versus the early stages of Covid-19 pandemic. We mostly studied contemporary documents on the Great Plague of Marseille, and collected press articles on Covid-19.

For both epidemics, some people see in the outbreak a sign of God's revenge. Logically, intensifying spiritual life and multiplying religious demonstrations can be a way to fight both epidemics. Studying religion in these times of epidemics also highlights its roles in public health: sometimes facilitating the contaminations if not regulated, sometimes supporting public health policies with some positions, as for Covid vaccines.

The comparison of an ancient epidemic with the current pandemic allowed us to take a broader look at the current vision of contagious disease, in societies that have become highly medicalized. The fight against epidemics remains polymorphous, and one of the aspects is religious. Integrating this information in our practices can help improving holistic management of patients, and public health policies efficiency.