Prediction Models for Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review and Meta-Analysis - 05/07/23
, Paula Dhiman, PhD 4, 5, Martijn J.J. Finken, MD, PhD 2, 3, Anton H. van Kaam, MD, PhD 1, 3, Trixie A. Katz, MD 1, 3, Joost Rotteveel, MD, PhD 2, 3, Ewoud Schuit, PhD 6, 7, Gary S. Collins, PhD 4, 5, Wes Onland, MD, PhD 1, 3, Heloise Torchin, MD, PhD 8, 9Abstract |
Objective |
To review systematically and assess the accuracy of prediction models for bronchopulmonary dysplasia (BPD) at 36 weeks of postmenstrual age.
Study design |
Searches were conducted in MEDLINE and EMBASE. Studies published between 1990 and 2022 were included if they developed or validated a prediction model for BPD or the combined outcome death/BPD at 36 weeks in the first 14 days of life in infants born preterm. Data were extracted independently by 2 authors following the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (ie, CHARMS) and PRISMA guidelines. Risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool (ie, PROBAST).
Results |
Sixty-five studies were reviewed, including 158 development and 108 externally validated models. Median c-statistic of 0.84 (range 0.43-1.00) was reported at model development, and 0.77 (range 0.41-0.97) at external validation. All models were rated at high risk of bias, due to limitations in the analysis part. Meta-analysis of the validated models revealed increased c-statistics after the first week of life for both the BPD and death/BPD outcome.
Conclusions |
Although BPD prediction models perform satisfactorily, they were all at high risk of bias. Methodologic improvement and complete reporting are needed before they can be considered for use in clinical practice. Future research should aim to validate and update existing models.
Le texte complet de cet article est disponible en PDF.Keywords : neonatology, prediction, chronic lung disease, premature
Abbreviations : 95% PI, BPD, PMA, PROBAST, RoB
Plan
| M.R. was supported by the Amsterdam Reproduction & Development Research Institute. P.D. was supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Oxford. G.C. was supported by the NIHR Biomedical Research Centre, Oxford, and Cancer Research UK (program grant: C49297/A27294). H.T. received grants from the French Society of Neonatology and from the French Society of Pediatrics. The authors declare no conflicts of interest. |
Vol 258
Article 113370- juillet 2023 Retour au numéro
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