Differences of Sex Development : Current Issues and Controversies - 28/06/23

Doi : 10.1016/j.ucl.2023.04.010

Emilie K. Johnson, MD, MPH ^a,^b,^⁎ , Jax Whitehead, MD ^c,^d, Earl Y. Cheng, MD ^a,^b
^a Division of Urology, Ann & Robert H. Lurie Children’s Hospital of Chicago, 225 East Chicago Avenue, Box 24, Chicago, IL 60611, USA
^b Department of Urology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair, Suite 2300, Chicago, IL, 60611, USA
^c Division of Endocrinology, Ann & Robert H. Lurie Children’s Hospital of Chicago, 225 East Chicago Avenue, Box 54, Chicago, IL 60611, USA
^d Department of Pediatrics, Northwestern University Feinberg School of Medicine, 225 East Chicago Avenue, Box 86, Chicago, IL 60611, USA

^∗Corresponding author. Division of Urology, Ann & Robert H. Lurie Children’s Hospital of Chicago, 225 East Chicago Avenue, Box 24, Chicago, IL 60611-2605.Division of UrologyAnn & Robert H. Lurie Children’s Hospital of Chicago225 East Chicago Avenue, Box 24ChicagoIL60611-2605

Résumé

Differences of sex development (DSD) encompass a broad range of conditions in which the development of chromosomal, gonadal, or anatomic sex is not typically male or female. Terms used to describe DSD are controversial, and continuously evolving. An individualized, multidisciplinary approach is key to both the diagnosis and management of DSD. Recent advances in DSD care include expanded genetic testing options, a more nuanced approach to gonadal management, and an emphasis on shared decision-making, particularly related to external genital surgical procedures. The timing of DSD surgery is currently being questioned and debated in both medical and advocacy/activism spheres.

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Keywords : Disorders of sex development, Intersex persons, Diagnosis, Patient care team, Patient advocacy