Comparison between 2D FSE T2-weighted Dixon MRI and contrast-enhanced 2D FSE and 3D FSPGR T1-weighted Dixon MRI to quantify inflammation in hands of patients with early rheumatoid arthritis - 23/06/23
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Highlights |
• | MRI protocol based on 2D fast spin-echo T2-weighted Dixon sequences and 3D fast spoiled gradient-echo T1-weighted Dixon imaging yields more accurate assessment of RAMRIS scoring in hands of patients with early rheumatoid arthritis. |
• | Contrast-enhanced 3D fast spoiled gradient-echo T1-weighted Dixon sequence yields higher scores of synovitis, tenosynovitis and erosions than 2D fast spin-echo T2-weighted Dixon sequence. |
• | 2D fast spin-echo T2-weighted Dixon imaging yields higher scores of osteitis than contrast-enhanced 3D fast spoiled gradient-echo T1-weighted Dixon imaging. |
Abstract |
Purpose |
The purpose of this study was to compare two-dimensional (2D) T2-weighted, contrast-enhanced 2D T1-weighted and contrast-enhanced three-dimensional (3D) T1-weighted Dixon MRI sequences to assess disease activity using the RAMRIS scoring system in hands of patients with early rheumatoid arthritis.
Materials and methods |
Twenty-five patients (19 women, 6 men; mean age 51.4 years ± 12.7 years [SD], age range: 28–70 years) with rheumatoid arthritis prospectively underwent MRI examination of both hands at 1.5 T using 2D fast spin-echo (FSE) T2-weighted, contrast-enhanced 2D FSE T1-weighted and contrast-enhanced 3D fast spoiled gradient echo (FSPGR) T1-weighted Dixon sequences. Three radiologists independently assessed disease activity according to RAMRIS using Dixon water-only and fat-only images. Intraclass correlation coefficients (ICC) were calculated to assess inter-technique and interobserver agreements.
Results |
Agreement to assess total RAMRIS score was very good between the MRI protocols (mean ICC ranging from 0.81 to 0.93) and between readers (mean ICC ranging from 0.91 to 0.94). Mean total RAMRIS scores of the three readers were significantly greater with contrast-enhanced 3D FSPGR T1-weighted (42.73 ± 29.39) than with contrast-enhanced 2D FSE T1-weighted (35.81 ± 25.48) and 2D FSE T2-weighted (32.20 ± 25.06) Dixon sequences.
Conclusion |
2D FSE T2-weighted, contrast-enhanced 2D FSE T1-weighted Dixon and contrast-enhanced 3D FSPGR T1-weighted Dixon protocols are reproducible alternatives for the RAMRIS scoring in hands of patients with early rheumatoid arthritis. Coupling contrast-enhanced 3D FSPGR T1-weighted and 2D FSE T2-weighted sequences might be the most efficient option to completely assess the rheumatoid arthritis -related synovial and bone changes with the Dixon method.
Le texte complet de cet article est disponible en PDF.Keywords : Contrast media, Gadolinium chelate, Magnetic resonance imaging, RAMRIS score, Rheumatoid arthritis, Three-dimensional imaging
Abbreviations : 2D, 3D, ACPA, CE, GBCA, FSPGR, ICC, IDEAL, LoA, MRI, OMERACT, RA, RAMRIS, FSE, SD, STIR
Plan
Vol 104 - N° 7-8
P. 351-358 - juillet 2023 Retour au numéro
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