Features of mixed medullary thyroid tumors: An NCDB analysis of clinicopathologic characteristics and survival - 17/06/23
Abstract |
Background |
Mixed medullary-papillary thyroid carcinoma (MMPTC) and mixed medullary-follicular thyroid carcinoma (MMFTC) are rare variants with little known regarding behavior and prognosis.
Methods |
Using the National Cancer Database (NCDB), demographics, clinicopathologic features, treatment, and overall survival (OS) from patients with MMPTC and MMFTC were compared to more prevalent subtypes.
Results |
There were 296,101 patients: 421 MMPTC (0.14%), 133 MMFTC (0.04%), 263,140 PTC (88.87%), 24,208 FTC (8.18%) and 8,199 MTC (2.77%). Compared to PTC, MMPTC and MMFTC patients were older (p < 0.001) with a higher Charlson-Deyo comorbidity index (p < 0.001). Mixed tumors exhibited lower rates of nodal disease but more distant metastases compared to PTC (p < 0.001). MMPTC demonstrated lower estimated 10-year OS than PTC and FTC (76.04%vs 89.04% and 81.95%,p < 0.001), yet higher than MTC (70.29%,p < 0.001). MMFTC had a worse OS compared to all groups (63.32%,p < 0.001).
Conclusion |
Patients with MMFTC had significantly worse OS compared to DTC, portending a worse prognosis.
Le texte complet de cet article est disponible en PDF.Highlights |
• | MMFTC exhibits worse overall survival when compared to MMPTC, MTC, FTC and PTC. |
• | Mixed medullary thyroid tumors present with more advanced disease. |
• | In both MMFTC and MMPTC patients of the lowest income cohort exhibited the greatest risk of mortality. |
Keywords : Endocrine surgery, Thyroid cancer, Mixed medullary thyroid carcinoma, National cancer database
Plan
Vol 226 - N° 1
P. 53-58 - juillet 2023 Retour au numéro
Article précédent
- Biologically inspired gastrointestinal stapler design: “Getting to Zero” complications
- John C. Alverdy
- Association between chronic steroids and outcomes in hepatobiliary and pancreatic surgery
- Faisal S. Jehan, Sangrag Ganguli, Cherilyn Song, Hassan Aziz
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?