Pleiotropic effects of Salacia reticulata and Simvastatin on oxidative stress and insulin resistance in a rat model - 17/06/23
, Manjunatha Bangeppagari b, 1, Venkata Lakshmi Narasimha Prasad Devarakonda c, Ramesh Bellamkonda d, Ramu Bhadramraju a, Srinivasan Kameswaran e, Rajendran Ramaswamy f, Saralakumari Desireddy a, ⁎ Abstract |
Background |
The present study investigated the effects of Salacia reticulata and simvastatin on oxidative stress and insulin resistance in Sprague-Dawley (SD) rats. We compared the protective effect of a methanolic extract of Salacia reticulata (SR) with simvastatin (SVS) in rats fed a high-fat diet (HFD).
Methods and results |
Male Sprague-Dawley rats were divided into the following five different groups: control (C), C+SR, HFD, HFD+SR, and HFD+SVS. High-fat diet fed rats showed hyperglycemia, hyperinsulinemia, hyperleptinemia, dyslipidemia, and hypoadiponectinemia after 90 days. Treatment of high-fat diet fed rats with SR/SVS significantly (p < 0.05) reduced high-fat diet induced increases in plasma triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and decreased high- density lipoprotein (HDL) accompanied by an increase in lipid peroxidation (LPO) and protein oxidation. In addition, a significant decrease in the activities of antioxidant enzymes and enzymes of the polyol pathway was observed in rats fed high-fat diet. SR was found to be more effective than SVS. Moreover, infiltration of inflammatory cells and fibrosis in the liver of high-fat diet fed rats by SR/SVS were also prevented.
Conclusions |
The present study confirms that SR/SVS may be a new and promising remedial approach because of its beneficial effects on the pathophysiological processes of obesity and related metabolic disorders.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Obesity is associated with inflammation and oxidative stress. |
• | SR/SVS alleviates HFD-induced insulin resistance, leptin resistance and lipid peroxide accumulation. |
• | SR/SVS remarkably reduced hepatic function markers and lipid profile in type 2 diabetic rats. |
• | SR/SVS exhibit very mild fatty changes with decreased granular degeneration in the liver. |
• | This study suggests the SR/SVS showed significant hepatoprotective effects in type 2 diabetic rats. |
Keywords : Salacia reticulata, High-fat diet, Oxidative stress, Insulin resistance, Metabolic syndrome
Plan
Vol 164
Article 114960- août 2023 Retour au numéro
Article précédent
- Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis
- Liping Hua, Shuangshuang Zhang, Jiali Yang, Xiaoqi Zhou, Senlin Shi
- Clinical impact of body mass index on palbociclib treatment outcomes and effect on exposure
- Rossana Roncato, Elena Peruzzi, Lorenzo Gerratana, Bianca Posocco, Sofia Nuzzo, Marcella Montico, Marco Orleni, Serena Corsetti, Michele Bartoletti, Sara Gagno, Giovanni Canil, Elena De Mattia, Jacopo Angelini, Massimo Baraldo, Fabio Puglisi, Erika Cecchin, Giuseppe Toffoli
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?