Genotype 4 Hepatitis E virus replicates in the placenta, causes severe histopathological damage, and vertically transmits to fetuses - 06/06/23
, Daqiao Wei a, ⁎ , Xiongwu Yu c, Fen Huang a, d, ⁎ Summary |
Background |
Hepatitis E virus (HEV) infection in pregnant women causes adverse pregnancy outcomes, including maternal death, premature delivery, stillbirth, and fetal infection. However, the pathogenesis of maternal and fetal HEV infection is unclear.
Methods |
Placenta and placental appendixes were collected from HEV-4 infected pregnant women to explore the vertical transmission of HEV from mothers to fetuses.
Results |
HEV-4 replicated in the placenta, placental membrane, and umbilical cord and was vertically transmitted from mothers to fetuses. HEV-4 placental infection resulted in serious histopathological damage, such as fibrosis and calcification, and severe inflammatory responses. Adverse maternal outcomes were observed in 38.5% of HEV-4 infected pregnant women. The distinct cytokine/chemokine expression patterns of HEV-infected pregnant women and nonpregnant women may contribute to the adverse pregnancy outcomes. Furthermore, the impaired maternal and fetal innate immune responses against HEV-4 facilitated viral replication during pregnancy.
Conclusion |
HEV-4 replicates in the placenta and is vertically transmitted from mothers to fetuses, causing severe histopathological damage.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Hepatitis E virus (HEV) infection in pregnant women causes adverse pregnancy outcomes. |
• | The pathogenesis of HEV through vertical transmission from mothers to fetuses is unclear. |
• | HEV-4 replication in the placenta resulted in serious fibrosis and calcification. |
• | Adverse maternal outcomes were observed in 38.5% of HEV-4 infected pregnant women. |
• | Severe inflammatory responses were found in HEV-4 infected placenta. |
Keywords : Hepatitis E virus, Placenta, Vertical transmission, Calcification, Cytokine/chemokine
Abbreviations : HEV, HEV-4, IHC, ISH, qRT-PCR, RIG-I, IFN, ELISA, PLS-DA, VIP, PROM, ISGs
Plan
Vol 87 - N° 1
P. 34-45 - juillet 2023 Retour au numéro
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