Impact of SARS-CoV-2 Omicron and Delta variants in patients requiring intensive care unit (ICU) admission for COVID-19, Northern Italy, December 2021 to January 2022 - 06/06/23
, Francesco Mojoli b, c, Laura Pellegrinelli d, Ferruccio Ceriotti e, Antonia Valzano e, Giacomo Grasselli f, Maria Rita Gismondo g, Valeria Micheli g, Antonio Castelli h, Claudio Farina i, Marco Arosio i, Ferdinando Luca Lorini j, Diana Fanti k, Andrea Busni k, Matteo Laratta l, Fabrizio Maggi m, Federica Novazzi m, Luca Cabrini n, Anna Paola Callegaro o, Roberto Keim p, Giuseppe Remuzzi q, Annalisa Cavallero r, Sergio Maria Ivano Malandrin r, Roberto Rona s, Federica Giardina a, Guglielmo Ferrari a, Federica Zavaglio a, Piera D'angelo a, Cristina Galli d, Laura Bubba d, Sandro Binda d, Massimo Oggioni e, Sara Colonia Uceda Renteria e, Patrizia Bono e, Andreina Baj m, Francesca Drago Ferrante m, Davide Guarneri i, Marco Tonelli i, Gavino Napolitano i, Alice Nava k, Lorenzo Romeo t, Elena Nicolini t, Rea Valaperta o, Ludovica Varisano o, Caterina Mele u, Lucia Liguori u, Monica Raggi r, Silvia Mongodi b, Michele Pagani b, Paolo Severgnini v, Dario Gasberti n, Ezio Bonanomi j, Paolo Gritti j, Francesco Marrazzo l, Ilaria Giovannini l, Noemi Sacchi p, Orlando Sagliocco p, Danilo Cereda w, Sabrina Buoro w, Fausto Baldanti a, c, Elena Pariani d
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Abstract |
This multicenter observational study included 171 COVID-19 adult patients hospitalized in the ICUs of nine hospitals in Lombardy (Northern Italy) from December, 1st 2021, to February, 9th 2022. During the study period, the Delta/Omicron variant ratio of cases decreased with a delay of two weeks in ICU patients compared to that in the community; a higher proportion of COVID-19 unvaccinated patients was infected by Delta than by Omicron whereas a higher rate of COVID-19 boosted patients was Omicron-infected. A higher number of comorbidities and a higher comorbidity score in ICU critically COVID-19 inpatients was positively associated with the Omicron infection as well in vaccinated individuals. Although people infected by Omicron have a lower risk of severe disease than those infected by Delta variant, the outcome, including the risk of ICU admission and the need for mechanical ventilation due to infection by Omicron versus Delta, remains uncertain. The continuous monitoring of the circulating SARS-CoV-2 variants remains a milestone to counteract this pandemic.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2, Intensive care unit (ICU), Severe infections, COVID-19, Omicron variant, Delta variant, Variant of Concern (VOC), Italy
Plan
Vol 83
Article 100990- juin 2023 Retour au numéro
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