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American Journal of Medicine, The

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Physical Activity, Sedentary Behavior, and Risk of Coronavirus Disease 2019 - 24/05/23

Doi : 10.1016/j.amjmed.2022.12.029 
Wenjie Ma, MBBS, ScD a, b, Erin Murray, MS c, Long H. Nguyen, MD, MS a, b, David A. Drew, PhD a, b, Ming Ding, ScD d, Konrad H. Stopsack, MD, MPH e, Janet W. Rich-Edwards, ScD, MPH e, f, Jaime E. Hart, ScD g, h, Jane C. Figueiredo, PhD i, James V. Lacey, PhD, MPH j, Alpa V. Patel, PhD k, Shilpa N. Bhupathiraju, PhD d, h, Andrew T. Chan, MD, MPH a, b, h, ⁎ , Maria Elena Martinez, PhD l, m
a Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 
b Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 
c Simmons University, Boston, Mass 
d Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Mass 
e Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Mass 
f Division of Women's Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 
g Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Mass 
h Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 
i Samuel Oschin Comprehensive Cancer Center at Cedars-Sinai, Los Angeles, Calif 
j Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, Calif 
k Department of Population Science, American Cancer Society, Kennesaw, Ga 
l Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla 
m Moores Cancer Center, University of California, San Diego, La Jolla 

⁎Requests for reprints should be addressed to Andrew T. Chan, MD, MPH, Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.Clinical and Translational Epidemiology UnitMassachusetts General Hospital55 Fruit StreetBostonMA02114
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Abstract

Introduction

Data on the associations of prepandemic physical activity and sedentary behavior with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) severity, particularly milder illness, have been limited.

Methods

We used data from 43,913 participants within the Nurses’ Health Study II and Health Professionals Follow-Up Study who responded to periodic COVID-related surveys from May 2020 through March 2021. History of physical activity from the prepandemic period was assessed as the metabolic equivalents of task (MET)-hours per week of various activities of different intensity and sedentary behavior assessed from reports of time spent sitting from questionnaires completed 2016-2017. Multivariable logistic regression models were fitted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for risk of SARS-CoV-2 infection and COVID-19 severity, as well as predicted COVID-19 defined using a validated symptom-based algorithm.

Results

Higher levels of prepandemic physical activity were associated with a lower risk for SARS-CoV-2 infection. Compared to participants with <3 MET-hours per week, the multivariable-adjusted OR was 0.86 (95% CI: 0.74, 0.99; P trend =.07) for those with ≥27 MET-hours per week. Higher physical activity levels were also associated with lower risk of symptomatic SARS-CoV-2 infection (OR: 0.84; 95% CI: 0.72, 0.99; P trend = .05) and predicted COVID-19 (OR: 0.87; 95% CI: 0.78, 0.97; P trend = .01). Longer time sitting at home watching TV (OR: 0.85; 95% CI: 0.73, 0.97) or for other tasks (OR: 0.78; 95% CI: 0.66, 0.92) was associated with a lower risk of SARS-CoV-2 infection.

Conclusions

Our findings support a protective association between prepandemic physical activity and lower risk and severity of COVID-19.

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Keywords : COVID-19, Physical activity, SARS-CoV-2 infection, Sedentary behavior


Plan


 Funding: This work was supported by grants U01 CA176726, U01 HL145386, U01 CA167552, and P30 ES000002 from the National Institutes of Health, the Harvard T.H. Chan School of Public Health Dean's Fund for Scientific Advancement: Acceleration Award, and Massachusetts Consortium on Pathogen Readiness COVID-19 Response Fund Award. The funders had no role in study design, data collection and analysis, interpretation of data, writing of the report, and decision to submit the paper for publication.
 Conflicts of Interests: None.
 Authorship: All authors had access to the data and a role in writing this manuscript.


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Vol 136 - N° 6

P. 568 - juin 2023 Retour au numéro
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