The application of hydrazones and hydrazide-hydrazones in the synthesis of bioactive azetidin-2-one derivatives: A mini review - 23/05/23
Abstract |
The hydrazones and hydrazide-hydrazones beside possessing crucial bioactivity can serve as useful intermediates in the synthesis of heterocyclic systems like 1,3-benzothiazin-4-one, 1,3-thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives. The azetidin-2-one derivatives show mainly antibacterial, antitubercular and antifungal activity as well as anti-inflammatory, antioxidant, anticonvulsant and antidepressant activity and activity against Parkinson’s disease. This review is focused on the literature reports which consider the synthesis and biological properties of azetidin-2-one derivatives.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Examples of bioactive azetidin-2-one are gathered in this review. |
• | Potential application of azetidin-2-one in the field of medicinal chemistry is presented. |
• | The azetidin-2-one derivatives show mainly antimicrobial, anti-inflammatory, antioxidant, anticonvulsant, antidepressant activity and activity against Parkinson’s disease. |
Abbreviations : A. clavatus, , A. flavus, , A. niger, , ABTS , , B. subtilis, , B. theobromine , , BSA , , C. albicans, , DPPH , , E. coli, , F . oxysporum , , I% , , ip , , K. pneumoniae, , MES , , MIC , , MBC , , MDR , , M. purpureus, , M. tuberculosis, , P. vulgaris, , P. aeruginosa, , P. citrinum, , P. chrysogenum, , PTZ , , RNS , , ROS , , SAR , , S. typhi, , sc , , SD , , S. aureus, , S. marcescens, , S. mutans, , S. pyogenes, , TB , , T. viride , , XDR ,
Keywords : Hydrazone, Hydrazide-hydrazone, Azetidin-2-one derivative, Biological activity, Antibacterial activity, Antifungal activity
Plan
Vol 163
Article 114853- juillet 2023 Retour au numéro
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