Prenatal and Childhood Smoke Exposure Associations with Cognition, Language, and Attention-Deficit/Hyperactivity Disorder - 05/05/23
, Trevin E. Glasgow, PhD 1, Julia C. Schechter, PhD 2, Rachel Maguire, MPH 3, 4, Yaou Sheng, MPH 5, Tatyana Bidopia, BS 2, D. Jeremy Barsell, MS 1, Albert Ksinan, PhD 6, Junfeng Zhang, PhD 7, Yan Lin, PhD 7, Cathrine Hoyo, PhD 3, Susan Murphy, PhD 8, Jian Qin, PhD 9, Xiangtian Wang, MS 7, Scott Kollins, PhD 10Abstract |
Objective |
To assess the relationships of prenatal and childhood smoke exposure with specific neurodevelopmental and behavioral problems during early childhood.
Study design |
A subsample (n = 386) of mother–child dyads from the Newborn Epigenetic Study (NEST) prebirth cohort participated in the study. Cotinine concentrations were used to objectively measure prenatal and childhood smoke exposure when youth were aged 3-13 years. Multivariable regression models were used to estimate associations of prenatal and childhood cotinine concentrations with performance on the National Institutes of Health (NIH) Toolbox and attention-deficit/hyperactivity disorder and behavioral symptoms, measured using the Behavior Assessment System for Children, 2nd edition (BASC-2).
Results |
After adjusting for confounders, childhood cotinine concentrations were associated with poorer cognitive performance on tasks measuring cognitive flexibility (B = −1.29; P = .03), episodic memory (B = −0.97; P = .02), receptive language development (B = −0.58; P = .01), and inhibitory control and attention (B = −1.59; P = .006). Although childhood cotinine concentration was associated with higher levels of attention problems (B = 0.83; P = .004) on the BASC-2, after adjustment for confounders, the association is nonsignificant. Although associations for maternal cotinine concentrations were null, an interaction was detected between prenatal and childhood cotinine concentrations on the NIH Toolbox Picture Vocabulary Task (P = .02).
Conclusions |
Our findings suggest that childhood tobacco smoke exposure may lead to poorer attention regulation and language acquisition, complex visual processing ability, and attention problems.
Le texte complet de cet article est disponible en PDF.Keywords : cotinine, tobacco, neurodevelopment, attention-deficit/hyperactivity disorder
Abbreviations : ADHD, BASC-2, CAARS, DCCS, FICA, NEST, NIH, PSM, PV, SHS, WASI-II
Plan
| Supported by the National Institute of Environmental Health Sciences (R01 ES016772, R21 ES014947, P01 ES022831, and R24 ES028531), the US Environmental Protection Agency (RD-83543701), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD084487), the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK085173), and the Duke Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. Further, the US Environmental Protection Agency does not endorse the purchase of any commercial products or services mentioned in this publication. In addition, this research was supported in part by the Intramural Research Program of the National Institute of Environmental Health Sciences. The authors declare no conflicts of interest. |
Vol 256
P. 77 - mai 2023 Retour au numéro
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