The role of KLF transcription factor in the regulation of cancer progression - 29/04/23
Abstract |
Kruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been found to play an essential role in the development of various human tissues, including epithelial, teeth, and nerves. In addition to regulating normal physiological processes, KLFs have been implicated in promoting the onset of several cancers, such as gastric cancer, lung cancer, breast cancer, liver cancer, and colon cancer. To inhibit cancer progression, various existing medicines have been used to modulate the expression of KLFs, and anti-microRNA treatments have also emerged as a potential strategy for many cancers. Investigating the possibility of targeting KLFs in cancer therapy is urgently needed, as the roles of KLFs in cancer have not received enough attention in recent years. This review summarizes the factors that regulate KLF expression and function at both the transcriptional and posttranscriptional levels, which could aid in understanding the mechanisms of KLFs in cancer progression. We hope that this review will contribute to the development of more effective anti-cancer medicines targeting KLFs in the future.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | General molecular characteristics and physiological function of KLF transcription factor. |
• | The modulation of KLF transcription factor in transcription and post-translation levels. |
• | KLF family members play different roles in cancers through various signaling pathways. |
• | Designing specific targets in regulating the expression of KLF is a potential therapy. |
Keywords : Kruppel-like factors, Cancer progression, Cancer therapy
Plan
Vol 162
Article 114661- juin 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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