Possible implication of estrogenic compounds on heart disease in menopausal women - 29/04/23
Abstract |
Epidemiological studies imply there is a higher risk of cardiovascular disease in menopausal women. Some explanations suggest a lack of estrogens as the cause, but estrogens do not disappear completely and are just transformed into different products called estrogenic degradation metabolites (EDMs). When estrogens are metabolized, reactive oxygen species (ROS) increase, causing DNA damage and increasing oxidative stress. These conditions are associated to neurodegenerative diseases and different types of cancer. However, their effect on the cardiovascular system remains unknown. This paper compares estrogenic metabolite levels in serum from post-menopausal women with cardiovascular risk (CAC>1) and with establish cardiovascular disease (CVD), against levels in healthy women (Ctrl). Sample sera were obtained from the Genetics of Atherosclerotic Disease (GEA) Mexican Study. Serum levels of eleven estrogenic metabolites were quantified by High performance liquid chromatography (HPLC) and oxidative stress markers such as ROS, lipoperoxidation levels (TBARS), total antioxidant capacity (TAC), super oxide dismutase activity (SOD) and cytokine levels were evaluated. 8-hydroxy-2-deoxyguanosine (8-OHdG) was also determined as a marker of nuclear damage.There were significant differences between serum levels of some EDMs in CAC> 1 and CVD vs. serum levels in Ctrl women. Results also revealed an increase in oxidative stress and a diminished capacity to manage oxidative stress. These findings provide an overview, and suggest that some estrogenic metabolites may be associated with an increased risk of CVD in menopausal women. However, additional studies are needed to evaluate the impact of these EDMs directly on cardiovascular function.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
● | Estrogenic degradation metabolites could be involved in CVD development. |
● | Estrogenic degradation metabolites levels vary not just in cancer also in cardiovascular diseases. |
● | Estrogenic degradation metabolites level differ among health post-menopausal women and those with CVD or in risk of. |
● | The so-called “good estrogen” (2-hydroxyestrone) seems to have a role in CVD development. |
Keywords : Estradiol, Estrone, Estriol, Estrogenic degradation metabolites, Menopause, Cardiovascular disease, Oxidative stress
Plan
Vol 162
Article 114649- juin 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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