Electroacupuncture at Neiguan (PC6) attenuates cardiac dysfunction caused by cecal ligation and puncture via the vagus nerve - 29/04/23
, Yiqiu Xia b, c, 1 , Chaofan Wang b, d, 1 , Wenjun Lu b , Han Zuo b , Dawei Wu a , Yu Li e , Rui Guo e , Jun Lu f, ⁎ , Luyao Zhang b, ⁎ Abstract |
Purpose |
Previous studies proved the benefits of electroacupuncture (EA) on heart in ischemia reperfusion injury and chronic heart failure. However, the role of EA on sepsis-induced cardiac dysfunction has rarely been elucidated before. In this study, we aimed to investigate the effects of EA on cardiac dysfunction in a rat model of sepsis and to speculate the underlying mechanisms.
Methods |
Sepsis was induced by cecum ligation and puncture in anesthetized rats. EA at the acupoint “Neiguan (PC6)” was applied 0.5 h after the induction of sepsis for 20 min. Heart rate variability was obtained immediately after EA to evaluate autonomic balance. Echocardiography was performed at 6 h and 24 h after sepsis induction in vivo. Measurements of hemodynamics, blood gases, cytokines and biochemistry were collected at 24 h. Cardiac tissue underwent immunofluorescence staining to determine the expression of α7 nicotinic acetylcholine receptor (α7nAChR) on macrophages.
Results |
EA increased vagus nerve activity, prevented the development of hyperlactatemia, attenuated the decline of left ventricle ejection fraction, suppressed systemic and cardiac inflammation and alleviated the histopathological manifestations of heart in sepsis rats. Furthermore, the cardiac tissue from EA treated rats showed increased expressions of α7nAChR on macrophages. The cardio-protective and anti-inflammatory effects of EA were partly or completely prevented in rats with vagotomy.
Conclusion |
EA at PC6 attenuates left ventricle dysfunction and decreases inflammation in sepsis-induced cardiac dysfunction. The cardio-protective effects of EA are mediated through vagus nerve mediated cholinergic pathway.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Electroacupuncture at PC6 improved left ventricle dysfunction in sepsis rats. |
• | Electroacupuncture inhibited inflammatory response in sepsis rats. |
• | The anti-inflammatory and cardio-protective effects of electroacupuncture depended on the vagus nerve. |
Abbreviations : MODS, EF, CLP, LV, EA, HRV, ECG, LF, HF, LVEF, MAP, BNP, cTnI, DAPI, pH, BE, PaO2, CAP, MIRI
Keywords : Electroacupuncture, Cardiac dysfunction, Cecal ligation and puncture, Vagus nerve, α7nAChR
Plan
Vol 162
Article 114600- juin 2023 Retour au numéro
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