Serum IFN-γ and RNAemia temporal profiles as biomarkers of severe COVID-19 in solid organ transplant and immunocompetent patients - 27/04/23

Doi : 10.1016/j.jinf.2023.01.019

Sonsoles Salto-Alejandre ^a,^b,^{^{1
These authors contributed equally to this work.}}, Marta Carretero-Ledesma ^a,^b,^{^{1
These authors contributed equally to this work.}}, Pedro Camacho-Martínez ^a,^b, Judith Berastegui-Cabrera ^a,^b, Carmen Infante ^a,^b, Regino Rodríguez-Álvarez ^c, Jorge Alba ^d, Patricia Pérez-Palacios ^b,^e, Emilio García-Díaz ^f, Cristina Roca ^a,^b, Julia Praena ^a,^b, María José Blanco-Vidal ^c, Sonia Santibáñez ^d, Rocío Valverde-Ortiz ^g, Javier Nieto-Arana ^c, Concepción García-García ^d, David Gutiérrez-Campos ^b,^e, Natalia Maldonado ^b,^e,^h, Gabriel Bernal ⁱ, Miguel Ángel Gómez-Bravo ^j, José Manuel Sobrino ^k, Manuela Aguilar-Guisado ^a,^b,^h, Rocío Álvarez-Marín ^a,^b,^h, Josune Goikoetxea-Aguirre ^c, José Antonio Oteo ^d, Zaira R. Palacios-Baena ^b,^e,^h, Álvaro Pascual ^b,^e,^h,^l, José Antonio Lepe ^a,^b,^h,^l, Jesús Rodríguez-Baño ^b,^e,^h,^m, José Miguel Cisneros ^a,^b,^h,^m, Jerónimo Pachón ^b,^m, Javier Sánchez-Céspedes ^a,^b,^h,^⁎ , Elisa Cordero ^a,^b,^h,^m
on behalf of The
COVIDSOT Working Team
^a Division of Infectious Diseases, Microbiology and Parasitology, Virgen del Rocío University Hospital, Seville, Spain
^b Institute of Biomedicine of Seville (IBiS), Virgen del Rocío and Virgen Macarena University Hospitals/CSIC/University of Seville, Seville, Spain.
^c Department of Infectious Diseases, Hospital Universitario Cruces, Bizkaia, Spain
^d Department of Infectious Diseases, San Pedro-CIBIR University Hospital, La Rioja, Logroño, Spain
^e Unit of Infectious Diseases and Microbiology, Virgen Macarena University Hospital, Seville, Spain
^f Medical Surgical Respiratory Unit, Virgen del Rocío University Hospital, Seville, Spain.
^g Unit of Nephrology, Virgen Macarena University Hospital, Seville, Spain
^h CIBERINFEC, ISCIII - CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain
ⁱ Unit of Urology and Nephrology, Virgen del Rocío University Hospital, Seville, Spain.
^j General and Digestive Service, Virgen del Rocío University Hospital, Seville, Spain.
^k Unit of Cardiology and Cardiovascular Surgery, Virgen del Rocío University Hospital, Seville, Spain.
^l Department of Microbiology, University of Seville, Seville, Spain
^m Department of Medicine, School of Medicine, University of Seville, Seville, Spain

^⁎Corresponding author at: Division of Infectious Diseases, Microbiology and Parasitology, Virgen del Rocío University Hospital, Av. Manuel Siurot s/n, Seville 41013, Spain.Division of Infectious DiseasesMicrobiology and ParasitologyVirgen del Rocío University HospitalAv. Manuel Siurot s/nSeville41013Spain

connectez-vous ou créez un compte

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Highlights

•	Highlights should be submitted in a separate editable file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, including spaces, per bullet point).
•	SOT recipients vs. no SOT patients have more undetectable IFN-γ and RNAemia rates.
•	Undetectable IFN-α rates are similar in SOT recipients and in no SOT patients.
•	In the no SOT patients, RNAemia and mortality decreased after 10 days of disease.
•	RNAemia is associated with unfavorable outcome in SOT recipients.
•	RNAemia and undetectable IFN-γ are associated with mortality in no SOT patients.

Le texte complet de cet article est disponible en PDF.

Export

Vol 86 - N° 5

P. 529-533 - mai 2023 Retour au numéro

Article précédent

The influences of the COVID-19 pandemic on Epstein-Barr virus infection in children, Henan, China
Ying Liang, Ligong Hou, Guangjun Hou, Xianwei Zhang, Lin Chen, Wancun Zhang

| Article suivant

A novel near-patient host-protein score predicts COVID-19 deterioration at presentation to secondary care
Rahul Atul Shah, Alexander J Mentzer, Tim James, Stuart Cox, Kevin Paddon, Jordan Bowen, James N Fullerton

Bienvenue sur EM-consulte, la référence des professionnels de santé.

connectez-vous ou créez un compte

Serum IFN-γ and RNAemia temporal profiles as biomarkers of severe COVID-19 in solid organ transplant and immunocompetent patients - 27/04/23

Highlights

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL