In recent decades, hepatitis has become a community health issue. A severe, asymptomatic and unobserved acute disease could be resulted by HCV and it could be treated completely in few cases or could result in chronic hepatitis.

The current research investigated the relationship among personality traits, coping strategies and quality of life in patients of hepatitis C in Pakistan.

Total 102 patients of HCV were selected from government, semi-government and private hospitals. Mental Health Screening Questionnaire (Mirza & Kausar, 2008) was used to screen the patients. The Urdu versions of Big Five Inventory (John & Srivastava, 1999), Coping Strategies Questionnaire (Kausar & Munir, 2004) and Quality of Life-BREF (1997) were used to measure the study variables.

The results showed that extraversion had positive relationship with the subscales of quality of life except physical health. Conscientiousness had positive relationship with physical and psychological health. Neuroticism had negative relationship with all the domains of quality of life. Openness to experience had positive relationship with psychological health and environment. religious coping and conscientiousness positively predicted physical health, whereas, agreeableness was the negative predictor of physical health. Psychological health and social relationships were positively predicted by active focused coping, whereas, neuroticism negatively predicted psychological health.

The results of present research indicated significant contribution of personality traits and coping strategies in maintaining quality of life of HCV patients. The clinical implications to improve quality of life of HCV patients are discussed in light of results.