Correlation between three-dimensional echocardiography and cardiopulmonary fitness in patients with univentricular heart: A cross-sectional multicentre prospective study - 15/04/23
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Highlights |
• | 3D echo variables in single ventricle correlate with cardiopulmonary fitness. |
• | 3D echo variables in single ventricle correlate with health-related QOL. |
• | 3D echo reproducibility in single ventricle is good. |
• | Feasibility of 3D echo in single ventricle should be improved. |
Abstract |
Background |
The prognosis of patients with a functional single ventricle has improved, with better cardiopulmonary fitness, health-related quality of life and survival. Conventional echocardiography remains the first-line technique in single ventricle follow-up. Three-dimensional (3D) echocardiography has shown recent value in congenital cardiology, but its ability to predict functional status in patients with a single ventricle remains unknown.
Aim |
To evaluate, in patients with a single ventricle, the association between 3D echocardiography variables and functional status determined by cardiopulmonary fitness.
Methods |
Children and adults with a functional single ventricle were prospectively enrolled in this multicentre study. Cardiopulmonary fitness was assessed by cardiopulmonary exercise test, with measures of maximum oxygen uptake (VO2max) and ventilatory efficiency (VE/VCO2 slope). 3D echocardiography was performed with off-line reproducibility analyses, using TomTec Arena™ software. Health-related quality of life was assessed using the SF-36 questionnaire.
Results |
A total of 33 patients were screened, and 3D echocardiography analyses were feasible in 22 subjects (mean age 28±9years). 3D echocardiography ejection fraction correlated with percent-predicted VO2max (r=0.64, P<0.01), VE/VCO2 slope (r=–0.41, P=0.05), two-dimensional echocardiography ejection fraction (r=0.55, P<0.01) and health-related quality of life physical functioning dimension (r=0.56, P=0.04). 3D echocardiography indexed end-systolic volume correlated with percent-predicted VO2max (r=–0.45, P=0.03) and VE/VCO2 slope (r=0.65, P<0.01). 3D echocardiography reproducibility was good.
Conclusions |
Single ventricle ejection fraction and volumes measured by 3D echocardiography correlated with cardiopulmonary fitness, as determined by two main prognostic cardiopulmonary exercise test variables: VO2max and VE/VCO2 slope. Despite good reproducibility, 3D echocardiography feasibility remained limited. 3D echocardiography may be of value in single ventricle follow-up, provided that the technique and analysis software are improved.
Le texte complet de cet article est disponible en PDF.Keywords : Single ventricle, Three-dimensional echocardiography, Aerobic fitness, Maximum oxygen uptake, Congenital heart disease
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| ☆ | Tweet: 3D echocardiography measures in univentricular heart correlate with cardiopulmonary fitness, as determined by VO2max and VE/VCO2 slope. 3D echocardiography may be of value in single ventricle follow-up, provided that the technique and analysis software are improved. |
Vol 116 - N° 4
P. 202-209 - avril 2023 Retour au numéro
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