Platelet lysate promotes hair growth: In vitro and in vivo mechanism and randomized, controlled trial - 28/03/23
, Zhi-qi Hu a, ⁎ , Qian Qu a, ⁎ Abstract |
Background |
Platelet lysate (PL), a novel platelet derivative, has been widely used in regenerative medicine and is a potential therapy for improving hair growth. It is necessary to fully clarify the potential mechanism and evaluate preliminary clinical effect of PL on hair growth.
Methods |
We used the C57BL/6 model, organ-cultured hair follicles, and RNA-seq analysis to explore the mechanisms of PL regulating hair growth. Then, we performed a randomized, controlled, double-blind study of 107 AGA patients to verify the therapeutic efficacy of PL.
Results |
The results confirmed that PL improved hair growth and accelerated hair cycling in mice. Organ-cultured hair follicle evaluation confirmed that PL prolonged anagen remarkably and down-regulated IL-6, C-FOS, and p-STAT5a. Clinically, diameter, hair counts, absolute anagen counts and changes from baseline in the PL group showed a significant improvement at 6 months.
Conclusions |
We elucidated the specific molecular mechanism of PL action on hair growth and proved equal changes in hair follicle performance after PL vs PRP in AGA patients. This study provided novel knowledge of PL, making it ideal for AGA.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Legend: PL imtproves hair growth. PL improves hair growth and accelerated hair cycling. In organ-cultured hair follicles, PL prolonged anagen remarkably and down-regulated IL-6, C-FOS, and p-STAT5a expression level.
Highlights |
• | Platelet lysate promoted hair growth in mice and organ-cultured hair follicles. |
• | Platelet lysate increased hair growth with no side effects in androgenic alopecia. |
• | Platelet lysate is promising to be a new choice for treatment of androgenic alopecia. |
Abbreviations : AGA, PRP, PL, PLm, PPP, HFSC, DPC, HF, KEGG, GO, DEG,
Keywords : Androgenic alopecia, Hair follicle, Platelet-rich plasma, Platelet lysate, Hair growth
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Vol 161
Article 114517- mai 2023 Retour au numéro
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