Maresin1 can be a potential therapeutic target for nerve injury - 28/03/23
Abstract |
Nerve injury significantly affects human motor and sensory function due to destruction of the integrity of nerve structure. In the wake of nerve injury, glial cells are activated, and synaptic integrity is destroyed, causing inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid, is a derivative of docosahexaenoic acid. It has showed beneficial effects in several animal models of central and peripheral nerve injuries. In this review, we summarize the anti-inflammatory, neuroprotective and pain hypersensitivity effects of maresin1 in nerve injury and provide a theoretical basis for the clinical treatment of nerve injury using maresin1.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Maresin1 can participate in the activation of nerve cell membrane and nuclear receptors, thereby regulating the survival of cytokines and cells. |
• | Maresin1 has anti-inflammatory, anti-pain hypersensitivity and neuroprotective effects. |
• | Maresin1 can provide a new method for the treatment of central and peripheral nerve injury. |
Abbreviation : PNI, CNS, SCI, PNS, VEGFB, DHA, RORα, 12-LOX, cAMP, SOD2, MCP, LPS, ALX, Sirt1, HIF-1α, Nrf2, STAT3, JAK, SOD1, TDP-43, DHA, Keap1, DRG, AMPK, BBB, P75NTR, MCAO, PSD95, TRPV1, ANO1, PLC, GPCR, SERCA, CGRP, CXCR2, CXCL1, NMDA, AMPA, PGE2
Keywords : Maresin1, Inflammation, Nerve injury, Therapeutic target, Macrophages, Neuronal protection
Plan
| ☆ | Grant sponsor: Zhejiang Provincial Natural Science Foundation of China supported this study under grant no. LY19H170001. |
Vol 161
Article 114466- mai 2023 Retour au numéro
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