Patient characteristics and eligibility for biologics in severe asthma: Results from the Greek cohort of the RECOGNISE “real world” study - 15/03/23
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Abstract |
Background |
Some patients with severe asthma do not achieve sufficient symptom control despite guideline-based treatment, and therefore receive oral (OCS) and systemic corticosteroids (SCS) on regular basis. The side effects of corticosteroid use negatively impact patients' health-related quality of life (HRQoL) and increase the disease burden. Biologics have shown promise in asthma therapy; however, identifying patients who might benefit from biologic therapy is complex due to the heterogeneous pathophysiology of the disease.
Methods |
The European, non-interventional, multicentre RECOGNISE study (NCT03629782) assessed patient characteristics, asthma medication and control, HRQoL as assessed by St. George's Respiratory Questionnaire (SGRQ), and health care resource use in patients with severe asthma, as well as their eligibility for biologic treatment. Here, data from the Greek cohort (N = 97) are reported.
Results |
In Greece, patients with severe asthma were more often female (71%) and never smokers (68%). 87% of patients were assessed as eligible for biologic treatment by investigator's judgement (per label criteria: 76%). Most patients had been previously treated with SCS (82% eligible vs 85% non-eligible), with OCS use being more common in non-eligible patients (23.1% vs 11.9%). More eligible patients had poorly controlled asthma (76% vs 54%), and more impaired HRQoL (mean total SGRQ score: 46% vs 39%); symptom burden was significantly higher (mean symptom score: 60% vs. 44%, p: 0.0389).
Conclusions |
A high proportion of Greek patients with severe asthma are eligible for biologic therapy; however, individual risk factors and differences between asthma types must be considered before the introduction of targeted therapy.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Most Greek severe asthma patients were eligible for biologics by investigator's assessment and by label criteria. |
• | Most patients had poor asthma control and markedly impaired health-related quality of life due to high symptom burden. |
• | Over 80% of the patients received systemic corticosteroids but a minority of them reported chronic oral corticosteroid use. |
• | Greek patients with severe asthma are more often never smokers. |
Keywords : Severe asthma, Eligibility for biologics, Greece, Health-related quality of life, Asthma control, RECOGNISE study
Plan
Vol 210
Article 107170- avril 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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