Prevalence of restrictive lung function in children and adults in the general population - 15/03/23
, Alina Ofenheimer a, b, Marie-Kathrin Breyer a, c, Tobias Mraz a, c, Bernd Lamprecht d, Otto Chris Burghuber a, e, Sylvia Hartl a, c, e, Emiel F.M. Wouters a, b, 1, Robab Breyer-Kohansal a, f, 1Abstract |
Background |
Restrictive lung function (RLF) is characterized by a reduced lung expansion and size. In the absence of lung volume measurements, restriction can be indirectly assessed with restrictive spirometric patterns (RSP) by spirometry. Prevalence data on RLF by the golden standard body plethysmography in the general population are scarce. Therefore, we aimed to evaluate the prevalence of RLF and RSP in the general population by body plethysmography and to determine factors influencing RLF and RSP.
Methods |
Pre-bronchodilation lung function data of 8891 subjects (48.0% male, age 6–82 years) have been collected in the LEAD Study, a single-centered, longitudinal, population-based study from Vienna, Austria. The cohort was categorized in the following groups based on the Global Lung Initiative reference equations: normal subjects, RLF (TLC < lower limit of normal (LLN)), RSP (FEV1/FVC ≥ LLN and a FVC < LLN), RSP only (RSP with TLC ≥ LLN). Normal subjects were considered those with FEV1, FVC, FEV1/FVC and TLC between LLN and ULN (upper limit of normal).
Results |
The prevalence of RLF and RSP in the Austrian general population is 1.1% and 4.4%. Spirometry has a positive and negative predictive value of 18.0% and 99.6% to predict a restrictive lung function. Central obesity was associated with RLF. RSP was related to smoking and underweight.
Conclusions |
The prevalence of true restrictive lung function and RSP in the Austrian general population is lower than previously estimated. Our data confirm the need for direct lung volume measurement to diagnose true restrictive lung function.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The prevalence of RLF and RSP in the general population are 1.1 and 4.4%, respectively. |
• | RSP has a high negative predictive value and low positive predictive value to define RLF. |
• | Body composition is an important determining factor of RLF and RSP. |
• | There is a need to combine lung function and body composition trajectories. |
Keywords : Pulmonary function testing, Spirometry, Body plethysmography, Restrictive lung function, Restrictive spirometric pattern, Prevalence, General population
Plan
Vol 210
Article 107156- avril 2023 Retour au numéro
Article précédent
- Frequency and characterization of CTEPH and CTEPD according to the mPAP threshold > 20 mm Hg: Retrospective analysis from data of a prospective PE aftercare program
- Matthias Held, Elena Pfeuffer-Jovic, Heinrike Wilkens, Gülmisal Güder, Franziska Küsters, Hans Joachim Schäfers, Heinz Jakob Langen, Danjouma Cheufou, Delia Schmitt
- Lung ultrasound as a tool for monitoring the interstitial changes in recently hospitalised patients with COVID-19 pneumonia - The COVIDLUS study
- Tuck-Kay Loke, Naomi Earl, Austin C.H. Begbey, Naveen Sharma, Niklas R. Wakeham, Hyon-Mok Sohn, Sarah J. Greenslade, Emma Ince, Miriam Davey, Karina Cox
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?