Effectiveness of BNT162b2 Vaccination During Pregnancy in Preventing Hospitalization for Severe Acute Respiratory Syndrome Coronavirus 2 in Infants - 14/03/23
, Liat Ashkenazi-Hoffnung, MD 3, 4, 5, Alejandro Diaz, MD 6, Amir Dov Erps, MD 3, Noa Eliakim-Raz, MD 4, 7, Yonat Shemer Avni, PhD 1, 8, David Greenberg, MD 1, 2, Noga Givon-Lavi, PhD 1, 2, ∗, Ilan Youngster, MD 4, 9, ∗
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Abstract |
Objective |
To assess the clinical effectiveness of the BNT162b2 vaccine during pregnancy in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospitalizations of infants.
Study design |
A retrospective, multicenter, 1:3 case-control (test-negative) study. Symptomatic hospitalized infants less than 6 months of age, with a positive SARS-CoV-2 polymerase chain reaction test between January 3, 2021, and March 11, 2021, were matched by age and time to negative controls, hospitalized with symptoms compatible with SARS-CoV-2 infection. Mothers were defined as fully vaccinated who received 2 doses of BNT162b2 with the second given 2 weeks to 6 months before delivery; or partially vaccinated, if they received only 1 dose or 2 doses with the second given more than 6 months or less than 2 weeks before delivery. Severe SARS-CoV-2 was defined as a need for assisted ventilation.
Results |
We matched 116 SARS-CoV-2 positive infants with 348 negative controls with symptoms compatible with SARS-CoV-2 infection. The effectiveness of fully vaccinated mothers was 61.6% (95% CI, 31.9-78.4) and the effectiveness of partially vaccinated mothers was not significant. Effectiveness was higher in infants 0-2 vs 3-6 months of age. The effectiveness (57.1%; 95% CI, 22.8-76.4) was similar when excluding mothers who were infected with SARS-CoV-2 during pregnancy. The OR of severe infection in infants born to unvaccinated vs fully vaccinated mothers was 5.8.
Conclusions |
At least 2 doses of BNT162b2 vaccine administered during the second or third trimester of pregnancy had an effectiveness of 61.6% in decreasing hospitalization for SARS-CoV-2 infection in infants less than 6 months of age.
Le texte complet de cet article est disponible en PDF.Keywords : Maternal vaccination, SARS-CoV-2, infants' hospitalizations, pregnancy
Abbreviations : SARS-CoV-2, PCR, mRNA, COVID-19, Ct
Plan
| All authors declare no support from any organization for the submitted work. D.D. has received a grant from Pfizer. D.G. has received grants from MSD, serves as scientific consultant to Pfizer, MSD, and GSK. These funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The other authors declare no conflicts of interest. |
Vol 254
P. 48 - mars 2023 Retour au numéro
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