Environmental risk of nontuberculous mycobacterial infection: Strategies for advancing methodology - 10/03/23

Doi : 10.1016/j.tube.2023.102305

Rachel A. Mercaldo ^a,^⁎ , Julia E. Marshall ^a , Gerard A. Cangelosi ^b,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Maura Donohue ^c,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Joseph O. Falkinham ^d,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Noah Fierer ^e,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Joshua P. French ^f,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Matthew J. Gebert ^e,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Jennifer R. Honda ^g,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Ettie M. Lipner ^a,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Theodore K. Marras ^h,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Kozo Morimoto ^i,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Max Salfinger ^j,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , Janet Stout ^k,^l , Rachel Thomson ^m,^{^{1
Environmental Risks for Nontuberculous Mycobacterial Lung Infections symposium panelist, listed alphabetically.}} , D. Rebecca Prevots ^a
^a Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA
^b Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
^c United States Environmental Protection Agency, Center for Environmental Solutions and Emergency Response, Cincinnati, OH, USA
^d Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA
^e Department of Ecology and Evolutionary Biology, Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO, USA
^f Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO, USA
^g Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA
^h Department of Medicine, University of Toronto and University Health Network, Toronto, Canada
ⁱ Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan
^j College of Public Health & Morsani College of Medicine, University of South Florida, Tampa, FL, USA
^k Special Pathogens Laboratory, Pittsburgh, PA, USA
^l Department of Civil and Environmental Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
^m Gallipoli Medical Research Institute & Greenslopes Clinical School, The University of Queensland, Brisbane, Australia

^∗Corresponding author.

Abstract

The National Institute of Allergy and Infectious Diseases organized a symposium in June 2022, to facilitate discussion of the environmental risks for nontuberculous mycobacteria exposure and disease. The expert researchers presented recent studies and identified numerous research gaps. This report summarizes the discussion and identifies six major areas of future research related to culture-based and culture independent laboratory methods, alternate culture media and culturing conditions, frameworks for standardized laboratory methods, improved environmental sampling strategies, validation of exposure measures, and availability of high-quality spatiotemporal data.

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Plan

Introduction

Recent advances in NTM environmental risk research

Environmental sampling and laboratory methods

Epidemiology and analytic methods

Knowledge gaps and areas of future research

Culture-based and culture-independent laboratory methods complement each other and should be used in tandem

Additional study is needed for novel media that may improve culture validity

Standardized laboratory methods are recommended, but effort and cooperation is necessary to establish a framework

The utility of exposure data depends on environmental sampling strategy

High-risk populations allow for efficient epidemiology, while a measure of exposure, not infection, will allow for more precise associations

Environmental epidemiology studies require high-quality spatiotemporal resolution

Summary and conclusions

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Vol 139

Article 102305- mars 2023 Retour au numéro

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Environmental risk of nontuberculous mycobacterial infection: Strategies for advancing methodology - 10/03/23

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