BCG vaccination induces enhanced humoral responses in elderly individuals - 10/03/23
, Chandrasekaran Padmapriyadarsini a, Anuradha Rajamanickam b, Perumal Kannabiran Bhavani a, Arul Nancy b, B. Jeyadeepa a, Rachel Mariam Renji b, Subash Babu bAbstract |
Background |
Studies have reported the beneficial effects of Bacillus Calmette Guerin (BCG) vaccination, including non-specific cross-protection against other infectious diseases.
Methods |
We investigated the impact of BCG vaccination on the frequencies of B cell subsets as well as total antibody levels in healthy elderly individuals at one month post vaccination. We also compared the above-mentioned parameters in post-vaccinated individuals to unvaccinated controls.
Results |
Our results demonstrate that BCG vaccination induced enhanced frequencies of immature, classical and activated memory B cells and plasma cells and diminished frequencies of naïve and atypical memory B cells. BCG vaccination induced significantly increased levels of total IgG subclass isotypes compared to baseline. Similarly, all of the above parameters were significantly higher in vaccinated individuals compared to unvaccinated controls.
Conclusion |
BCG vaccination was associated with enhanced B cell subsets, suggesting its potential utility by enhancing heterologous immunity.
Le texte complet de cet article est disponible en PDF.Keywords : B cells, BCG, Humoral immunity, COVID-19
Abbreviations : BCG, GM, TB, UVC
Plan
Vol 139
Article 102320- mars 2023 Retour au numéro
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