Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants - 05/03/23
on behalf of the
Antifungal study group
Highlights |
• | SOFA score ≥ 7 and GGT ≥ 100 associated with fluconazole underexposure. |
• | A median loading dose of 890 mg (640–3450) needed to avoid underexposure. |
• | Fluconazole therapeutic drug monitoring for critically ill patients. |
Abstract |
Objectives |
This study aims at evaluating fluconazole exposure in critically ill patients and identifying variables associated with the latter.
Patients and methods |
This was a 2-year (2018–2019) retrospective multicenter cohort study. Adult patients > 18 years-old with at least one fluconazole concentration measurement during their ICU stay were included.
Results |
Twenty patients were included. Only 11 patients had a fluconazole trough concentration (Cmin) within the target range (≥15 mg/L). According to bivariable analysis, SOFA score, GGT, fluconazole clearance, Ke, and Vd, were independently associated with a decrease in fluconazole Cmin. The median loading dose required to achieve the Cmin target appeared to be greater in patients with higher SOFA or GGT level and in patients undergoing renal replacement therapy.
Conclusions |
This study supports recommendation for routine fluconazole therapeutic drug monitoring in ICU patients so as to avoid underexposure, especially if SOFA score is ≥ 7 and/or GGT is ≥ 100 U/L.
Le texte complet de cet article est disponible en PDF.Keywords : Antifungal stewardship, Critically ill patients, Fluconazole, Pharmacokinetic, Therapeutic drug monitoring
Plan
Vol 53 - N° 2
Article 104630- mars 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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