Pharmacological mechanism of natural drugs and their active ingredients in the treatment of arrhythmia via calcium channel regulation - 26/02/23
, Ruxiu Liu a, ⁎ Abstract |
Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused by heart pacing and conduction dysfunction. Arrhythmia is the leading cause of death in patients with cardiovascular disease, with high morbidity and mortality rates, posing a serious risk to human health. Natural drugs and their active ingredients, such as matrine(MAT), tetrandrine(TET), dehydroevodiamine, tanshinone IIA, and ginsenosides, have been widely used for the treatment of atrial fibrillation, ventricular ectopic beats, sick sinus syndrome, and other arrhythmia-like diseases owing to their unique advantages. This review summarizes the mechanism of action of natural drugs and their active ingredients in the treatment of arrhythmia via the regulation of Ca2+, such as alkaloids, quinones, saponins, terpenoids, flavonoids, polyphenols, and lignan compounds, to provide ideas for the innovative development of natural drugs with potential antiarrhythmic efficacy.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | The dysfunction of Ca2+ channels are important factors that induce arrhythmias. |
• | Natural drugs maintain calcium homeostasis via calcium channel regulation. |
• | Natural drugs and their active ingredients may be a promising anti-arrhythmic drug. |
Abbreviations : LTCCs, Ca2+, TTCCs, SR, IcaT, AF, IcaL, RYR2, SERCA2a, KCNA5, NCX1, INCX, H/R, SSS, ROS, PVCs, CaMKII, DAD, EAD, ARVC, MAT, OMT, Soph, NF-kB, AB, NFAT, APD, ATP, INaL, INaT, IKr, INa, ERP, TET, I/R, ATX II, Ito, Pro, IK, Iks, DeHE, IsoRhy, GFA, EMA, SUMO, RES, Ang1–7, JWS, BrS, ERS, Arc, 6-Gin, PI3K-Akt-mTOR pathway, CX43, CaM, AMI
Keywords : Natural drugs, Calcium channel, Arrhythmia, Pharmacological mechanism
Plan
Vol 160
Article 114413- avril 2023 Retour au numéro
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